Standard addition is not a very capable echnique against ESI MS matrix effects, because it assumes linearity and matrix effects are often strongly non-linear. Our more recent investigations clearly show that the best technique against matrix effects is Extrapolative dilution.

]]>i’d really like to be able to read the articles, because i am actually working in the develop of a multiresidue method for determining pesticides in fruits by LC – ESI MS/MS. I just realized i have problems with the matrix effect in the interface ESI, i was researching how to deal with this problem, and i found your web page.

I am very sure your investigation would be very useful to resolve my big problem.

Actually, we are not allowed to suscribe any web page for a while, that is why i am asking for your help with this articles.

Thank you so much for your time and for the help you are providing to all people involved in investigation.

Best Regards

Sergio Maquilon

Cromatography Department